Practice and Deliberation of Integration of PBL with CBL Teaching Mode on the Teaching of Precision Medicine for Diabetes in Undergraduate Students

Li-mei Liu, Gui-hua Jian, Yan-jun Liu


In recent years, the transition in the classification of diabetes and the establishment of four types of diabetes are the evidence for diagnosis and treatment of diabetes to orient and challenge precision medicine. Maturity onset diabetes of the young (MODY) is the most common form in special type of diabetes. The misdiagnosis rate of MODY is extremely high in diabetes due to its overlapping with type 1 diabetes and type 2 diabetes in some non-characteristic phenotypes. Therefore it is no time to delay to start the education on precision medicine of diabetes in undergraduate students. Integration of problem-based learning (PBL) with case-based learning(CBL) teaching mode was applied in the teaching for precision medicine of diabetes in undergraduate students, wherein a proposed case with MODY, was misdiagnosed as type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) successively, and eventually the classificatory diagnosis and individualized drug targeted therapy of this case were completed by etiological analysis and screening of pathogenic genes regarding to phenotypes and mechanism. Practice has proved that starting and implementing precision medicine teaching for diabetes by the application of integration of PBL with CBL teaching mode in undergraduate students, may effectively promote the precise classification and precise treatment, which is regarded as the goal for the process of precision medicine of diabetes.


Diabetes; Precision medicine; Problem-based learning (PBL); Case-based learning (CBL); Integration

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Journal of Education in New Century

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