Screening of mouse strain susceptive to chronic stress depression and preliminary research of its susceptive mechanism

Long-jin XU, Ke-zhou Wang

Abstract


Objective: To screen mouse strain that susceptive to chronic unpredicted mild stress (CUMS) and preliminarily research its susceptive mechanism. Methods: KM, ICR, BABL/c and C57BL/6 mice were used to establish CUMS depression model. Body weight, sucrose preference test (SPT), open field test (FT) were used to evaluate the sensitivity of mice to CUMS. Hippocampal levels of glucocorticoid receptor (GR), 5-hydroxytryptamine (5-HT), kynurenine (KYN) were measured and used for susceptive mechanism research. Results: Body weight, SPT, horizontal movement score and vertical movement score of C57BL/6 mice were found to susceptive to CUMS. SPT, horizontal movement score and vertical movement score of BABL/c showed similar tendency. Hippocampal levels of GR and KYN of normal C57BL/6 mice were significantly lower or higher than that of normal KM, ICR and BABL/c mice. Conclusions: Our study has led to the view that C57BL/6 mice are susceptive to CUMS and hippocampal levels of GR and KYN may be the main mechanism responsible for its susceptibility.


Keywords


Mouse; Chronic stress; Susceptive strain; Susceptibility mechanism

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DOI: http://dx.doi.org/10.14725/gjph.v2n3a1516

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Global Journal of Public Health  

 ISSN 2372-5923(Online)