Green synthesis in acid water of 5,7,3’,4’-O-tetramethylquercetin

Zhong-lei Wang, Li-yan Yang, Shuai Cui, Ying-xi Liang, Jian-na Yuan, Ling-zhi Wang, Xiao-hua Zhang


Objective: To synthesize 5,7,3′,4′-O-tetramethylrutin. Methods: With absolute N,N-dimethylformamide as the solvent, rutin and methyl iodide were stirring reaction at room temperature for 48h in the presence of potassium carbonate to obtain 5,7,3′,4′-O-tetramethylrutin, after filtering, rinsing with acetone and concentration under reduced pressure. The concentrate was heated and refluxed for about 1h in 0.50% hydrochloric acid, and then cooled and filtered. The precipitation was washed to neutral with distilled water. Results: The synthesis of 5,7,3′,4′-O-tetramethylquercetin was achieved through the steps above, and it has the same anti-influenza virus effect with oseltamivir, the yield was 92.2%. Conclusion: This method owns the characteristics of high yield, simple process, stable and feasible.


Rutin; Synthesis; Anti-influenza virus; 5,7,3′,4′-O-tetramethylquercetin

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Global Journal of Integrated Chinese Medicine and Western Medicine

ISSN 2308-6025 (Print)  ISSN 2375-4710 (Online)