Effect of Compound Danshen Dripping Pill on circadian blood pressure, high sensitive C reactive protein and cardiac function in patients with non dipper hypertension

Abstract

Objective: To investigate the effect of Compound Danshen Dripping Pill on circadian blood pressure, high sensitive C reactive protein and cardiac function in patients with non dipper hypertension. Methods: According to ABPM nocturnal blood pressure decline rate < 10%, select 178 patients whose systolic pressure and diastolic pressure meet the standards, 88 cases were divided into treatment group, and the rest 90 cases were in control group. All patients were having the levoamlodipine maleate 2.5mg, 1 time a day, the blood pressure still > 140 / 90mmHg, the addition of Stan. The treatment group were treated with 10 Compound Danshen Dripping Pills, 3 times a day, June. ABPM and hs-CRP, ultrasonic Beckoning figure was examined before and after treatment.Results: All the patients completed the study in June, by antihypertensive drugs and compound Danshen dripping pills after treatment, consulting room (CSBP and CDBP) and BP are parameters of ABPM increased significantly (P < 0.01). Partial parameters compared with the control group after treatment were significantly different (P < 0.05). Systolic blood pressure, diastolic blood pressure, circadian variation rate level, variation rate and high sensitive C reactive protein of the treatment group after treatment were significantly improved compared with the control group (P < 0.05). The treatment group after treatment of diastolic function improved significantly (P < 0.05), the control group after treatment had no obvious improvement. Systolic function of two groups before treatment increased slightly, no statistical significance (P > 0.05).Conclusion: Long-term use of Compound Danshen dripping pill can improve the circadian rhythm of blood pressure in patients with non dipper hypertension, reduce the high sensitive C reactive protein level, improve cardiac diastolic function.