Analysis of the relation between uric acid and malignant ventricular arrhythmia in patient with dilated cardiomyopathy

Kai Wu, Yin Gao, Jin-sheng Li, Hu Wei, Xiao-ping Chen

Abstract


To analyze the relation between uric acid (UA) and malignant ventricular arrhythmia (MVA) in patient with dilated cardiomyopathy (DCM), and to provide clinic basis for predicting the risk of death. Methods: We divide the 48 patient with dilated cardiomyopathy into 2 groups according to MVA. They are MVA group and normal group. We analyze the difference of the incidence of hyperuricemia (HUA) between the 2 groups. Results: ⑴ The indices of age, creatinine (Crea), uric acid, N-terminal pro-brain natriuretic peptide (NT-proBNP), left ventricular end-diastolic volume (LVEDV) and the percentage of  HUA and ventricular late potential (VLP%) in MVA group are higher than those in normal group, as to left ventricular ejection fraction (LVEF), the normal group is higher than that in MVA group. And the difference between the two groups is statistically significant. There is no statistically difference in the indices of proportion of men, systolic blood pressure (SBP) and heart rate(HR) between the 2 groups. ⑵Using logistic regression, MVA was positively related to UA, VLP, age, NT-proBNP and LVEDV, and it is negatively related to LVEF. Conclusions: MVA is closely related to uric acid. Uric acid might be used to predict the incidence of MVA in patient with DCM.

Keywords


Uric acid(UA); Malignant ventricular arrhythmia(MVA); Dilated cardiomyopathy(DCM); Hyperuricemia(HUA)

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DOI: http://dx.doi.org/10.14725/gjccd.v4n1a1396

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Global Journal of Cardiovascular and Cerebrovascular Diseases

ISSN 2309-3374 (Print)  ISSN 2375-4095 (Online)